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Medical Equipments Medical Updates Medicine & Health

Serum Institute to produce Ebola vaccine for use in Uganda outbreak

Synopsis
The Serum Institute of India plans to manufacture 20,000 to 30,000 doses of an experimental Ebola vaccine by the end of November for use in trials against an outbreak in Uganda, its developers and a company source said.

The Serum Institute of India plans to manufacture 20,000 to 30,000 doses of an experimental Ebola vaccine by the end of November for use in trials against an outbreak in Uganda, its developers and a company source said.
The response to Uganda’s outbreak has been blunted by the absence of a proven vaccine against the Sudan strain of the virus.

There have been 54 confirmed cases and 19 deaths since last month and the first case in the capital, Kampala, was recorded last week. But health authorities believe the actual numbers could be higher.

Vaccines against the more common Zaire strain of Ebola have proven highly effective during recent outbreaks in neighbouring Democratic Republic of Congo.

Serum Institute to produce Ebola vaccine

Oxford University’s Jenner Institute, which developed a COVID-19 vaccine with AstraZeneca, has an Ebola vaccine that has been shown to induce an immune response to both the Sudan and Zaire strains in Phase 1 trials.

Its developers said it could be deployed in Uganda as part of a clinical trial once the authorities there gave regulatory approval.

“We are working very closely with Serum Institute to rapidly scale up the manufacture of this vaccine,” said Teresa Lambe, the chief scientific adviser on Ebola at the Jenner Institute.

“We are hoping to have a large number of doses, approximately 20,000 to 30,000 or more by mid-to-end of November,” she told Reuters.

A source at the Serum Institute, the world’s biggest vaccine maker and part of a conglomerate run by Indian billionaire Cyrus Poonawalla, confirmed this information. The source said the Ebola vaccine doses would be supplied free of cost.

‘PLAYING CATCH UP’

Uganda’s Information Minister Chris Baryomunsi said in an interview on Saturday that he did not have any information on a vaccine rollout but that the outbreak was under control.

President Yoweri Museveni said the same day that the government would implement an overnight curfew and restrict movement into and out of two districts in central Uganda affected by Ebola for 21 days.

World Health Organization (WHO) chief Tedros Adhanom Ghebreyesus said last week that clinical trials of two vaccines could begin in the coming weeks pending Ugandan government approvals, without naming the vaccines.

There are at least six vaccines in development for the Sudan strain, including three with Phase 1 data, according to WHO.

The Oxford researchers voiced frustration that their vaccine was not ready to be rolled out when the outbreak hit, saying governments around the world had not made investing in vaccines enough of a priority in the wake of the COVID-19 pandemic.

The vaccine has been in development for several years but its progress through clinical trials has been slowed by funding shortfalls, they said.

“With better investment the world could easily have ready-made vaccines sitting in vials for this and a number of other diseases,” said Sandy Douglas, an investigator at the Jenner Institute.

“We’re spending a couple of months now playing catch up on work that could have been done ahead of time.”

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COVID-19 Government Guidelines Medical Updates Medicine & Health

Harnessing the power of partnerships in expanding Covid vaccine coverage

On the first anniversary of India’s COVID-19 vaccination drive, the Hon’ble Health Minister, Mansukh Mandaviya, observed that Jan Bhagidari helped to fuel India’s achievements in its successful vaccination journey. This, in fact, echoes the sentiment of Hon’ble Prime Minister of India, Narendra Modi, who emphasizes that the functioning of any robust democracy lies in the power of the collective that Jan Bhagidari stands for.

As someone with extensive experience in of public health, this principle has always resonated with me. I do believe that it’s the coming together of so many people – healthcare professionals, the larger scientific community, vaccine manufacturers, development partners, local leaders and frontline health workers all under the leadership of the Government of India – that has ensured India’s success in administering more than 2 billion COVID-19 vaccine doses to its eligible population in record time.

I am proud to be associated with a project that has contributed in its own way toward India’s exceptional vaccination trajectory: the MOMENTUM Routine Immunization Transformation and Equity Project. Operational across 18 states and union territories, and supported by USAID, the project has been a key driver in augmenting the efforts of the Ministry of Health and Family Welfare to improve the uptake of COVID-19 vaccination across states in record time. In many ways, it carries forward the country’s legacy of reaching the unreached, leaving no one behind and ensuring everyone has equitable access to vaccines.

Harnessing the power of partnerships in expanding Covid vaccine coverage

From hard-to-reach areas; tribal communities where confidence in and awareness about vaccines tends to be lower; vulnerable groups such as migrant workers, transgenders, elderly, disabled people, pregnant and lactating mothers– the project has helped to weave a safety net for those at the margins. Most importantly, the project has reiterated the country’s strength of successful collaborations — in this case, with multiple local partners at the state and community levels across a diverse mix — health workers, community champions, faith-based leaders, beneficiaries-turned-influencers and others.

For instance, in Chhattisgarh, an influencer from the trans community ensured that gender doesn’t become a barrier to availing the benefits of a life-saving vaccine. This influencer, Kanchan Sendre, worked hard to ensure an uptick in vaccinations for her community – she was so effective that she earned the title, ‘Vaccine Didi’. In Punjab, collaborations were done with the Shiromani Gurdwara Parbandhak Committee which ensured that all visitors could undergo the immunization process during their visit to the iconic Golden temple. In Madhya Pradesh, key religious and community leaders of Taj-Ul Masjid — one of Asia’s biggest mosques — came forward to help organize a large-scale COVID-19 vaccination-cum-awareness session. More than 400 key religious leaders from various parts of the state and the Director of Immunization of MP participated to increase awareness levels about COVID-19 and the vaccine.

Assam saw the innovative ‘Wellness on Wheels’ initiative — a vehicle with Covid-19 vaccination messages. The vehicle enabled vaccinators to reach out to remote villages and vaccinate vulnerable people who may otherwise struggle to access healthcare. In fact, this initiative saw a total of over 51,000 vaccinations (as on Sep 30, 2022), covering over 1200 villages.

To a large extent, the project typifies the essence of Jan Bhagidari. At every level, every stakeholder has played a significant role to ensure that the greater goal of vaccines for all is achieved. It is only apt to say that that these achievements have come at a time when India is celebrating Azadi ka Amrit Mahotsav. This is also a time to acknowledge that projects such as this have successfully developed strategies to mobilize communities by developing locally contextual interventions.

In this context, there are two standout cases illustrative of the power of people: polio and tuberculosis. In Uttar Pradesh, perhaps the most inventive tool was the Bulawa Toli – a children’s brigade would go through neighborhoods shouting slogans and inviting younger children to visit the nearest polio booth for the vaccine. When it comes to TB, community engagement has been critical too. Earlier this year, another strong example of community-focused initiative by the government came in the form of the Ni-kshay Mitra under the ‘Pradhan Mantri TB-Mukt Bharat Abhiyaan.’ As part of this initiative, a range of stakeholders – cooperative societies, corporate entities, elected representatives, non-governmental organizations, political parties and individuals etc. – can consider supporting and adopting districts and blocks or even one or more TB patients across states in India, in the fight against TB.

From the time of its launch on September 9, approximately 10.5 lakh TB patients have consented to receive nutritional, diagnostic, and vocational support in their journey of battling TB. As of now, over 33,000 people from various backgrounds have signed up as Ni-kshay Mitras, who will now be providing nutrition and other support to over 10.2 lakh patients – an example of how society can truly unite to overcome any adversity. And the numbers are increasing at a rapid pace.

Across different public health issues, the nature of interventions may change. But what has consistently helped our country overcome all obstacles, has been the ability to galvanize the community. And to further strengthen the efficacy of community action vis-à-vis public health, it’s important to continually work toward devising locally-relevant solutions for optimal impact. All this ties in with the broader tenets of Jan Bhagidari, too. I am confident that with such strong foundations, the country’s healthcare systems will be secure and stronger than ever before.

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Medical Updates Medicine & Health

Air pollution scare rises in Delhi: Health consequences you should be aware of

As Delhi has started breathing bad air, it is mandatory to note the health consequences that the population residing in the national capital are prone to.

As per a 2021 report on Air Quality Life Index released by the University of Chicago’s Energy Policy Institute: India is the most polluted country in the world, with more than 510 million people—or about 40 percent of the country’s

population—living in the Indo-Gangetic plains of Northern India where pollution levels regularly exceed those found anywhere else in the world by an order of magnitude. The residents of this region, which includes the megacities of Delhi and Kolkata, are on track to lose more than 9 years of life expectancy if 2019 concentrations persist.

It also added that in Bangladesh, India, Nepal, and Pakistan, the AQLI data reveal that the average person would live 5.6 years longer if pollution were reduced to meet the WHO guideline.

Air pollution scare rises in Delhi: Health consequences you should be aware of

Exposure to air pollution can cause both short term and long term complications to the health. Severe health complications happen when the air is laden with fine PM2.5 particles which easily enter the body and settle in the lungs.

Air pollution can worsen the existing asthma condition in people and can also trigger a new attack.

“Breathing ozone and particle pollution can lead to increased asthma attacks,” warns the American Lung Association.

The US Environmental Protection Agency says in 2018, six million kids in the US were affected with Asthma due to air pollution.

A research study by the Children’s Center at Stanford University found that short-term and long-term exposures to high levels of carbon monoxide, nitrogen dioxide, and PM 2.5 were associated with alterations to the two genes responsible for immune tolerance in children and concluded that those alterations were significantly associated with asthma.

A September 2022 study published in the Lancet has talked about how increasing air pollution levels increases the risk of lung cancer, mesothelioma, and cancers of the mouth and throat.

Another study by the UK’s Francis Crick Institute and University College London found that people regularly exposed to higher levels of PM2.5 air pollution were at increased risk of epidermal growth factor receptor mutant lung cancer and other cancers

Long term exposure to pollutants in the air can also lead to chronic bronchitis, chronic obstructive pulmonary disease or COPD, pneumonia, and even heart diseases.

It can also lead to central nervous system dysfunctions.

The intensity and the occurence of these diseases varies from individual to individual depending on their existing health condition, age and sex. It also depends on the lifestyle of the individuals.

Several factors render air in Delhi unbreathable.

Stubble burning, construction activities, industrial releases and vehicles contribute the most to Delhi’s sickening pollution.

A 2016 study by IIT Kanpur, Delhi Pollution Control Committee and Department of Environment, NCT Delhi found that road dust accounts for more than 50% of the air pollution in the city.

“The most health-harmful pollutants – closely associated with excessive premature mortality – are fine PM2.5 particles that penetrate deep into lung passageways,” warns the WHO.

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Medical Updates Medicine & Health

Colorectal cancer patients can benefit from surveillance with chest imaging

Despite improved survival rates, colorectal cancer is the third leading cause of cancer-related deaths in the United States. Though rates of colorectal cancer have declined among people 65 and older, largely thanks to increased screening efforts, rates among younger adults are rising.

According to new research presented at the Scientific Forum of the American College of Surgeons (ACS) Clinical Congress 2022, colorectal cancer patients with certain clinical characteristics may benefit from more frequent chest imaging to help identify and target cancer that has spread to the lungs.

These findings have the potential to improve long-term outcomes of patients with metastatic colorectal cancer.

Despite improved survival rates, colorectal cancer is the third leading cause of cancer-related deaths in the United States. Though rates of colorectal cancer have declined among people 65 and older, largely thanks to increased screening efforts, rates among younger adults are rising. 2 When the cancer is caught early, many patients can remain disease-free for the rest of their lives after surgical treatment, but colorectal cancer can spread (metastasize) in up to 50 per cent of patients.

 

One of the most common areas colorectal cancer spreads to is the lungs, affecting up to 18 per cent of patients with colorectal cancer.4 Detecting cancerous nodules in the lung early provides patients with the best outcomes, but there are no evidence-based standards for when and how often to screen colorectal cancer patients with chest CT or PET scans.

Colorectal cancer patients can benefit from surveillance with chest imaging

“After patients are diagnosed with colorectal cancer, many of them want to better understand what their cancer diagnosis entails in terms of their surveillance and survivorship for the rest of their life, but we currently lack data and uniform guidelines to support how often these patients should be screened with chest imaging,” said co-author Mara Antonoff, MD, FACS, associate professor, thoracic and cardiovascular surgery, UT MD Anderson Cancer Center, Houston, where she also serves as program director of education.

Anderson added, “With this study, we sought to develop a strategy that is evidence-based to determine how frequently, at what intervals, and for how long patients at risk of developing lung metastases should undergo imaging of their chest.”

Dr. Antonoff specializes in thoracic surgical oncology and has a clinical interest in colorectal cancer that has spread to the lungs. She is leading a multi-institutional study, under the umbrella of the American Association for Thoracic Surgery (AATS) Thoracic Surgery Oncology Group (TSOG) (TSOG 103), on developing optimal treatment strategies for colorectal cancer patients whose cancer spread is limited to the lungs.

To identify which colorectal cancer patients may benefit from early chest imaging and at what time intervals, Dr. Antonoff and an interdisciplinary team of researchers at MD Anderson – including cardiothoracic surgeons, colorectal cancer surgeons, and gastrointestinal oncologists – collaborated on this research project to investigate evidence-based surveillance guidelines for colorectal patients who are at risk of developing lung metastases.

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Medical Updates Medicine & Health

Indian pharma to step up quality standard to meet global generic demand

Synopsis

In 2019, Indian pharma companies received 19 warning letters. Nearly half were from the Office of Manufacturing Quality, US Food and Drug Administration (FDA). GoI has taken some measures since March 2021. Companies that manufacture and market pharmaceuticals are accountable for their products’ quality. That is not enough. A regulatory overhaul is needed.

The possible link between four cold and cough syrups made by an Indian pharmaceutical company and the death of 66 children in the Gambia is a wake-up call. The World Health Organisation (WHO) has issued a global alert to minimise and prevent further harm.

For India’s drug regulator and government, this is an alarm to step up vigilance. India must continue to be the ‘pharmacy to the world’ by ensuring that the quality of its products is not suspect. For this, GoI must take strong measures.

Indian pharma to step up quality standard to meet global generic demand

India is the third-largest pharma manufacturer, meeting 20% of global generic demand. Multiple assessments project the industry to grow further – $45-65 billion by 2025, and $120-130 billion by 2030. However, non-compliance with quality standards is the biggest challenge.

In 2019, Indian pharma companies received 19 warning letters. Nearly half were from the Office of Manufacturing Quality, US Food and Drug Administration (FDA). GoI has taken some measures since March 2021. Companies that manufacture and market pharmaceuticals are accountable for their products’ quality. That is not enough. A regulatory overhaul is needed.

The current fragmented system, where quality and standardisation become casualties, must be replaced by a modern, independent, statutory regulatory system. The Central Drugs Standard Control Organisation (CDCSO) is the non-statutory regulator under the health ministry. It has no jurisdiction over State Drug Regulatory Authorities that are part of state health departments. Each regulatory body acts independent of the other. This must change.

The pandemic has raised concerns about supply chains and inequity in access. Failure to address quality standards could derail the prospects of one of India’s brightest sectors.

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Government Guidelines Medical Updates Medicine & Health

Maiden Pharmaceuticals had license to export, not locally sell cough & cold syrup, India says

Synopsis

India’s health and welfare ministry said Thursday that Maiden Pharmaceuticals had the license to only export four drugs that are now linked to have killed 66 children in Gambia. ​​​​”Four drugs, out of 23, named Promethazine Oral Solution BP, Kofexnalin Baby Cough Syrup, MaKoff Baby Cough Syrup and MaGrip n Cold Syrup, are not sold in India,” stated a press release.

India’s health and welfare ministry said Thursday that Maiden Pharmaceuticals had the license to only export four drugs that are now linked to have killed 66 children in Gambia.

“Four drugs, out of 23, named Promethazine Oral Solution BP, Kofexnalin Baby Cough Syrup, MaKoff Baby Cough Syrup and MaGrip n Cold Syrup, are not sold in India,” stated a press release.

It also said that the company has manufactured and exported these products only to Gambia.

Maiden Pharmaceuticals had license to export, not locally sell cough & cold syrup, India says

WHO had informed DCGI, the National Drug Regulator of India, that it is currently providing technical assistance and adviced to Gambia, where children have died and where a contributing factor, is suspected to be the use of medicines which may have been contaminated with Diethylene glycol or Ethylene glycol (in some of the samples it was claimed to have been confirmed by further analysis conducted by WHO).

CDSCO took up the matter immediately with Haryana State Regulatory Authority, under whose jurisdiction the drug manufacturing unit of M/s Maiden Pharmaceutical Limited, Sonepat is located. Further, a detailed investigation was launched to ascertain the facts/ details in the matter in collaboration with State Drugs Controller, Haryana.

From the preliminary enquiry of CDSCO, it has been made out that Maiden Pharmaceutical is a manufacturer licensed by the State Drug Controller for the products and holds manufacturing permission for these products for export only. The company has manufactured and exported these products only to Gambia.

As per the tentative results received by WHO, out of the 23 samples of the products under reference which were tested, four samples were found to contain Diethylene Glycol/ Ethylene Glycol. It has also been informed by WHO that the certificate of analysis will be made available to WHO in near future and it will share it with the Indian Regulator which is yet to be done. The exact one to one causal relation of death has not yet been provided by WHO to CDSCO.

As a robust National Regulatory Authority, CDSCO has requested WHO to share at the earliest with CDSCO the report on establishment of causal relation to death with the medical products in question etc.

“The samples (controlled samples of the same batch manufactured by M/s. Maiden Pharmaceuticals Limited for all the four drugs in question) have been taken and sent for testing to Regional Drug Testing Lab, Chandigarh by CDSCO, the results of which will guide further course of action as well as bring clarity on the inputs received/ to be received from WHO,” the release stated.

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COVID-19 Medical Updates

Omicron’s staying power is key to mild winter as cases rise

The rhythm of pre-pandemic life is back around much of the world. Munich’s Oktoberfest tents are full, tourists are returning in Tokyo and New York, masks have come off in the subways.

The rhythm of pre-pandemic life is back around much of the world. Munich’s Oktoberfest tents are full, tourists are returning in Tokyo and New York, masks have come off in the subways. The previous two autumn seasons ended with new Covid-19 variants spurring fresh waves of cases and social restrictions. This year is different: the super-contagious but less severe omicron has shown unusual staying power — even as it spawned hundreds of sublineages.

The world has learned that the coronavirus is fickle, and as cases start to creep up again, so does concern about unpredictable developments. But if omicron’s dominance holds, it could point to a drift reminiscent of the flu’s annual changes and pave the way for Covid to settle into a more predictable pattern.

Omicron’s staying power is key to mild winter as cases rise

Any successor to omicron will face an uphill battle. It will need to be both more transmissible and better able to sidestep the immunity people have built, said Ralf Bartenschlager, a German virologist and professor at Heidelberg University.

“It’s like throwing dice,” Bartenschlager said in an interview. “During the replication of the virus, the dice are constantly thrown, and the best-fitting number gets an advantage.”

“We can even be happy — in quotation marks — that we now have an omicron variant that has taken over from the original strains,” he added.

The World Health Organization is tracking more than 300 sub-lineages of omicron, officials there said last week. The BA.5 subvariant that swept across the globe this summer still dominates, accounting for some four-fifths of sequences.

The multiplicity of sublineages is in some ways closer to what scientists would have expected compared with the way previous major variants emerged “out of nowhere,” looking very different than the strains that had previously dominated, said Stephen Goldstein, an evolutionary virologist at the University of Utah.

Omicron’s staying power is key to mild winter as cases rise

“It’s totally possible that some strange new combination of mutations is emerging in some person who is chronically infected and that could spark a new variant,” he said, “but we don’t have the ability to predict that.”

The more infections there are, the higher the chances of unpredictable developments. And cases are on the upswing from Germany to China, which remains the notable exception to the reopening trend as the government sticks to its Covid-zero policy.

“I know some would love to believe that the pandemic is over,” Moderna Inc.’s chairman, Noubar Afeyan, said in an interview with Bloomberg TV. “But as the saying goes, ‘We may be done with the pandemic, but the pandemic doesn’t seem to be done with us.”’

Another complicating factor is that as countries roll back their testing programs, genetic surveillance is declining as well, Maria Van Kerkhove, the WHO’s Covid technical lead, said at a briefing. The number of sequences being evaluated has dropped by more than 90% since the start of the year, she said, limiting the WHO’s ability to track subvariants as efficiently.

“What we don’t know is is how this virus will continue to change,” Van Kerkhove said Wednesday. “We know it will change.”

That means it’s too soon to say with certainty what will happen next. Making predictions would be akin to looking into a crystal ball, said Bartenschlager. And we won’t know that we’ve hit what could be an annual pattern until it’s repeated, according to Goldstein.

“What we have going on right now is a kaleidoscope of factors that all play into what will be our future with Covid,” said Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota.

Despite the avalanche of research, he said there’s still a lot that scientists have yet to learn. “If there was ever a time for humility in public health, it’s now.”

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COVID-19 Government Guidelines Medical Updates Medicine & Health

India records 2,424 new coronavirus infections, 3 deaths

New Delhi: India saw a single day rise of 2,424 new coronavirus infections taking the total tally of COVID-19 cases to 4,46,14,437, while the active cases have declined to 28,079, according to the Union Health Ministry data updated on Monday.

The death toll has climbed to 5,28,814 with 15 fatalities which include 12 deaths reconciled by Kerala, the data updated at 8 am stated.

The active cases comprise 0.06 per cent of the total infections, while the national COVID-19 recovery rate has increased to 98.75 per cent, the health ministry said.

A decline of 514 cases has been recorded in the active COVID-19 caseload in a span of 24 hours.

India records 2,424 new coronavirus infections, 3 deaths

The daily positivity rate was recorded at 2.65 per cent, while the weekly positivity rate was recorded at 1.27 per cent, according to the health ministry.

The number of people who recuperated from the infection surged to 4,40,57,544, while the case fatality rate was recorded at 1.19 per cent.

According to the ministry, 218.99 crore doses of COVID vaccine have been administered in the country so far under the nationwide COVID-19 vaccination drive.

India’s COVID-19 tally had crossed the 20-lakh mark on August 7, 2020, 30 lakh on August 23, 40 lakh on September 5, and 50 lakh on September 16.

India crossed the grim milestone of two crore on May 4, three crore on June 23 2021, and four crore on January 25 this year.

The three new fatalities reported in 24 hours include two from Kerala and one from West Bengal.

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Medical Updates Medicine & Health

Impact of over working out on a healthy heart

We see that there are various unforeseen incidents that are happening daily with fit youngsters and people from other age groups, due to ignorance towards heart health. It could be an impact of over working out on a healthy heart.

While ‘no pain, no gain’ is a very common saying amongst people who workout, this is not necessarily the truth in more scenarios as it can lead to overtraining, which is often a phenomenon that most people fail to realize while it’s happening. We see that there are various unforeseen incidents that are happening daily with fit youngsters and people from other age groups, due to ignorance towards heart health hence, it is of utmost priority and importance to raise concerns about these issues and talk about the right way towards a healthy heart and its health.

The body undergoes stress during exercise and while some stress is good, constant and additional stress after a certain point is not. In an interview with HT Lifestyle, Spoorthi, Fitness expert at Cult.fit, cautioned, “Not realizing one’s maximum threshold and continuing to workout in such a condition can be fatal. While you exercise, your heart helps to circulate blood throughout the body. It contracts faster and circulation is increased. This means that the muscles receive oxygenated blood much faster. While muscles also help to circulate blood, your heart does most of the work. Working out in moderation helps improve this process and strengthen the muscles of the heart.”

She explained, “When you overtrain, the demand for blood to the muscles is going to increase and the heart will overwork in trying to meet the demands. Your heart rate increases and so does the speed of the contractions along with the force of pumping blood. Tracking your heart rate and heart rate variability is one way to ensure you’re not overworking your heart. High variability in heart rate is something you can look out for. This can also be due to various other factors such as recovery and sleep. To summarize, overtraining can lead to the heart working harder, hence leading to cardiovascular conditions. You can ensure you don’t overtrain by getting optimal rest, eating well to fuel your body enough, and tracking your heart rate so you can modify your workouts.”

Impact of over working out on a healthy heart

Warning about the same, Dr V Vinoth Kumar, Senior Consultant, Interventional Cardiology at CARE Hospitals of HITEC City in Hyderabad, revealed, “People develop heart attacks and other heart-related issues varying from mild to severe during workouts and marathons. One of the main reasons is a structural abnormality. This is often seen in people with narrowed or smaller aortic valves that pump limited blood to the body. Physical activities that demand more blood for the body will be strenuous as the heart cannot provide it. Furthermore, Hypertrophic cardiomyopathy (HCM), an abnormally thick heart muscle is common in people under 30 years who may suddenly collapse due to heavy physical activities. Alternatively, there may be blockages in the blood vessels of the heart even in the heart of young adults leading to sudden cardiac arrests. Both HCM and blockages are seen in youngsters as it may be genetic in a few cases Parents who have experienced early age heart complications before the age of 50, at times pass it on to their children as well.”

He suggested, “It is important to get a regular cardio check-up of 2D Echo and ECG which reflects the condition of the heart. Blockage of less than 70% goes unnoticed in tests. Perfectly healthy hearts that has 10-20% blockage suddenly results in 100% blockage and cardiac arrests in heavy smokers. It is best to avoid smoking as it directly impacts the heart. People with diabetes, need to control their sugar levels while working out on a regular basis. In conclusion, heart evaluation by a cardiologist and regular monitoring by a professional while working out are very important. Increasing the workout plans gradually is the best route rather than jumping to heavy physical exercises and activities.”

It is well known that exercise is good for us, but at the same time, extreme activity which pushes the healthy limits can be dangerous. Dr Gopi A, Director – Interventional Cardiology at Fortis Hospital in Bangalore, shared, “Chronic extreme exercise training and competing in endurance sports like marathons can lead to both heart damage and heart disorders. This is common in people who have genetic risk factors for such abnormalities. One should not put away their walking shoes as moderate exercise is the best prescription for good physical and mental health. All extreme athletic activities have been linked to certain cardiac complications. When marathon runners are examined, after a marathon or after any chronic endurance sport, by blood foot biomarkers like troponin or CPK and MB, a higher level of biomarkers is found in these patients. Higher levels of biomarkers suggest minimal amount of cardiac damage.”

He elaborated, “When this happens, once in a while, the heart can repair itself and get back to normal but if it happens repeatedly over a short period of time, it can damage and result in some remodelling of the heart. As a result of it, the patients will have thicker heart muscles and there will be areas of scarring in the heart, which can lead to certain complications later on. In addition to this, very high intensity exercises, short bursts can be dangerous for the heart, they can acutely increase the risk of sudden cardiac arrest or sudden cardiac death. So many of the celebrities’ mortalities have taken place on the field or on a football ground. Moderate exercises like walking, jogging and swimming are ideal for people facing cardiac concerns. 150 to 300 minutes moderate intensity of exercise per week, is advised. This has got multiple benefits in terms of weight reduction, improvement in blood pressure, controlled diabetes, better sleep and stress management. To sum it up, exercising in moderation is good, but high intensity exercise has got its own risks. It is highly recommended to undergo a proper health check-up before getting into high intensity exercises.”
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COVID-19 Government Guidelines Medical Updates Medicine & Health

COVID symptom list has changed; THESE are the common signs of the infection now, experts say

The order of COVID symptoms, from the most prevalent ones to the least, can be said to have changed. Two years into pandemic, health experts have seen a shift in the occurrence of COVID symptoms. The symptoms which are tagged as the ‘common symptoms’ are the red flags and should be dealt with proper preventive measures and, if necessary, medical intervention.

Apart from fever, headache, and other cold-related symptoms, the most common symptom seen during the onset of COVID infection these days is sore throat.

COVID symptom list has changed; THESE are the common signs of the infection now, experts say

 

Tim Spector, PhD, a professor of genetic epidemiology at King’s College London and co-founder of the COVID ZOE study app says that two-thirds of people with COVID are seen having sore throats as a symptom.

In a report carried by the Independent, Spector said that fever and loss of smell and taste are hardly seen in people these days.

In a report released on September 1, Spector’s Zoe COVID app had said that loss of appetite still remains one of the typical symptoms of COVID. “Early in the pandemic, loss of appetite was reported by around three in ten adults with COVID, rising to roughly four in ten people over 65,” the report says and adds that it has now fallen slightly with subsequent variants and vaccination, with just over a quarter of people (25-27%) reporting skipping meals with Delta or Omicron after three doses of the vaccine.

The other symptoms of COVID which are also commonly seen in people are runny nose, headache, sneezing, persistent cough, shortness of breath and sometimes fever.

Fatigue continues to persist in people during and after COVID and is currently seen as a big indicator of long COVID condition, in which the symptoms are seen in the individual weeks and months after a COVID infection.

Apart from these diarrhea, chest pain, tinnitus, sleep issues, loss of memory and focus should not be ignored if these persist for a longer time.

The fact that people are not updated with the new COVID symptoms, they live under the impression that they do not have COVID. Fever has always been seen as the primary key symptom of COVID ever since the pandemic happened. However, these days no fever does not mean you do not have COVID. With a sore throat and a mild headache there are chances you might have contracted the viral infection.

Fever and loss of smell are really rare now, so many old people may not think they’ve got COVID. They’d say it’s a cold and not be tested, Spector told the newspaper.

The lack of awareness around symptoms hampers the pace of testing and surveillance. People who are only aware about the outdated symptoms of the infection do not test themselves. As a result of which the infection keeps on spreading.

This also reduces the chance of identifying a newer variant quickly. More testing will lead to more effective tracking of the super-mutating coronavirus.

India recorded less than 2,000 COVID cases in the last 24 hours as per the data shared by the Union Health Ministry. India’s active COVID caseload currently stands at 30,362. The recovery rate stands at 98.75% with 3,908 recoveries in the last 24 hours. While the daily positivity rate stands at 0.94% the weekly positivity rate stands at 1.34%.

With COVID cases dropping and hinting better days, Delhi government is planning to withdraw the COVID restrictions.

Delhi Disaster Management Authority (DDMA) has announced that the Rs 500 penalty for not wearing masks in public places in Delhi has been withdrawn.

However, wearing masks is advisable if you are in a crowded place or are sick and can not avoid staying indoors.

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