Tag: Corona Updates

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Government Guidelines Medical Updates Medicine & Health

Heart damage: Another reason to cut down on children’s screen time

Heart damage: Another reason to cut down on children’s screen time

Evidence indicates that excessive screen time is harmful both to neurological development and socialisation.

The effects of prolonged screen use during childhood have been extensively studied in recent years. Evidence indicates that excessive screen time is harmful both to neurological development and socialisation. This is because, among other things, they cause us to disconnect from our surroundings, leading to very real addictions that often require intervention from a mental health professional.

Additionally, screen use can cause neurocognitive learning disorders at the early stages of personality formation in childhood.

But above all, excessive time spent in front of televisions, video games, mobile phones and tablets during childhood and adolescence leads to a sedentary lifestyle.

In fact, there is already a proven link between overuse of screens and the increase in sedentary lifestyles among children.

Now, a new dimension can be added to all these reasons for limiting the time children spend in front of televisions, video games and mobile phones.

According to a new study, led by Andrew Agbaje at the University of Eastern Finland in Kuopio and presented at the European Society of Cardiology Congress 2023, sedentary children are at increased risk of heart damage in early adulthood.

Heart damage: Another reason to cut down on children’s screen time

In other words, inactivity during infancy may well set the stage for heart attacks and strokes later in life, even if weight and blood pressure are within the normal ranges.

Excessive screen time increases heart weight

The research analysed the cumulative effects of sedentary time on the heart, drawing data from Children of the 90s, a landmark multigenerational study that is unique in its breadth and depth of scope.

It tracked the health and lifestyles of 14,500 babies born in 1990 and 1991 into their adult lives.

Of the children included in the study, 766 –55 per cent of them girls and 45 per cent boys– were asked at age 11 to wear a smart watch that monitored their activity for seven days.

At age 15 they were asked to repeat this, and then again at 24. In parallel, an echocardiographical analysis was taken of each subject’s left ventricle at ages 17 and 24, which was then adjusted for height, sex, blood pressure, body fat, tobacco use, physical activity and socioeconomic status.

The results indicated that at age 11 the subjects were sedentary for an average of 362 minutes per day.

In adolescence (age 15) this increased to 474 minutes per day, and then went up to 531 minutes per day in adulthood (age 24).

Sedentary time increased by an average of 2.8 hours per day over the 13 years of the study.

A large amount of this sedentary time was spent in front of screens. `Most seriously, the echocardiography registered an increase in heart weight among young people that correlated directly to time spent being sedentary.

Once they entered adulthood, this increased the likelihood of heart attacks and strokes.

This direct relation between accumulated inactive time and heart damage was independent of body weight and blood pressure.

Tell me how much you moved as a child…

By now it is common knowledge that sedentary lifestyles increase the risk of metabolic conditions (such as obesity and type 2 diabetes), neurodegenerative disease and cardiovascular disease in adults.

The new study shows that sedentary behaviour at a very early age –especially unrestricted screen time– may lead to an earlier onset of cardiovascular disease in adulthood.

For this reason, it is of the utmost importance that parents encourage children and adolescents to move around more, and limit the time they spend watching television, or using social media and videogames.

As we have already suggested with regard to premature birth, the list of known, conventional cardiovascular risk factors (smoking, diabetes, hypertension, etc.) should be revised and updated as a result of the study to include the cumulative time spent engaging in sedentary behaviour in childhood.

We should all, from an early age, heed the words of Martin Luther King when he said “If you can’t fly, then run. If you can’t run, then walk. If you can’t walk, then crawl, but whatever you do, you have to keep moving.”

Read more at- https://shorturl.at/rvxO3

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Government Guidelines Medical Updates Medicine & Health

Long Covid patients are much more likely to have multiple organ abnormalities

Long Covid patients are much more likely to have multiple organ abnormalities

MRI scans revealed that people with long COVID were 14 times more likely to have lung abnormalities than people who never had the disease.

It wasn’t that long ago that some people speculated that long COVID was all in the mind – a psychosomatic illness. Thankfully, that period of speculation is now behind us. We have compelling evidence that long COVID is very real and very harmful. I’m the lead investigator on an ongoing study called C-More which looks at the long-term harms caused by COVID.

People with long COVID who had abnormalities involving more than two organs were four times more likely to report “severe” or “very severe” mental and physical impairment.

In the beginning

When COVID first emerged, doctors perceived it to be a respiratory illness, with patients reporting pronounced coughing, shortness of breath and symptoms akin to pneumonia.

But as our global understanding of the disease evolved, so did our appreciation of this complex disease.

Reports began to emerge that the virus was capable of not just affecting the lungs but also other organs, such as the heart, kidneys, brain and blood vessels, causing a broader assault.

Studies identifying the viral proteins in various organs also began to emerge, demonstrating the virus’s fondness for certain tissues that were not part of the lungs.

Originally, the main theory put forward was that SARS-CoV-2 (the virus that causes COVID) was directly infecting cells across multiple organs.

But, as data accumulated, a more nuanced understanding emerged. It was observed that in some patients, the immune system, in its defence against the virus, overshot its response, leading to what’s termed a “cytokine storm”.

This hyperactive immune reaction wasn’t always discriminative, causing unintended damage to organs not directly under viral attack.

Further reports highlighting the predisposition of the virus to induce excess clotting, mitochondrial disruption (mitochondria being the powerhouses of our cells) and reactivation of other viruses emerged.

Long Covid patients are much more likely to have multiple organ abnormalities

More importantly, there was a growing number of patients continuing to report persistent disabling symptoms arising from multiple organs, even after surviving the initial infection, also known as long COVID, a condition now thought to affect one in ten people.

So the narrative shifted. COVID wasn’t merely a short respiratory affliction, but a multisystem disease with the potential for long-term complications, challenging our assumptions about how to treat the disease.

The birth of C-More

To shed light on these questions, the C-More study was launched in the UK, focusing on the after-effects of the virus in patients who had been hospitalized.

Few studies on long COVID have looked at multiple organ harm in the same patient. And those that have, have tended to focus on patients who weren’t hospitalized with COVID.

This makes our study unique. However, as with any pioneering study, there are some limitations.

The latest results, mentioned above, are based on preliminary data (interim analysis from half the study population). A complete analysis is still awaited.

Pre-COVID MRI scans from patients were not available, making definitive conclusions about the link between COVID and the organ changes difficult.

The control participants were not an exact match to the patient population, but we adjusted our analyses to account for any differences, ensuring the findings were as accurate as possible.

The MRI scans didn’t always explain the symptoms experienced in individual organs.

For instance, even if the MRI showed an organ to be normal, a patient could still exhibit related symptoms. The only strong tie identified was between lung abnormalities and chest tightness.

Still, this study was an important effort to better understand the long-term effects of COVID on multiple organ health.

It reminds us to be vigilant of the potential for long-term consequences of the disease and the importance of vaccination – particularly in people at risk of severe infections.

Doctors and healthcare services around the world can now refine follow-up care, with a focus on lung, brain, kidney and blood vessel health among patients recovering from serious COVID infections, based on our study’s results.

Read more at-https://shorturl.at/ewIZ9
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COVID-19 Government Guidelines Medical Updates Medicine & Health

‘Disease X’ could be 20 times deadlier than COVID-19, says expert

'Disease X' could be 20 times deadlier than COVID-19, says expert

UK healthcare professionals are preparing for a potential new pandemic known as ‘Disease X,’ which could be more deadly than COVID-19, with the capacity to result in 20 times more fatalities. Disease X could potentially cause up to 50 million deaths.

As COVID-19 transitions into a recurring and more familiar health concern, healthcare professionals in the UK are now gearing up for a potential new pandemic known as “Disease X.” They caution that this new virus could have a similar impact to the devastating Spanish Flu of 1918-1920.

Health experts are sounding the alarm about “Disease X,” a term coined by the World Health Organization. They warn that this potential new pandemic has the capacity to result in 20 times more fatalities than the coronavirus. The COVID-19 pandemic began in 2020 and has tragically claimed the lives of over 2.5 million people worldwide. Here are the top 10 points about Disease X.

1. In an interview with the Daily Mail, Kate Bingham, who served as the chair of the UK’s Vaccine Taskforce from May to December 2020, expressed her belief that Disease X is expected to be considerably more perilous than COVID-19.

 

2. Based on expert estimates, Disease X could potentially result in up to 50 million fatalities. “Let me put it this way: the 1918-19 flu pandemic killed at least 50 million people worldwide, twice as many as were killed in World War I. Today, we could expect a similar death toll from one of the many viruses that already exist,” she told the Daily Mail.

In response to Disease X, Bingham asserted, “the world will have to prepare for mass vaccination drives and deliver the doses in record time.”

'Disease X' could be 20 times deadlier than COVID-19, says expert

3. She disclosed that while scientists have identified 25 virus families encompassing thousands of individual viruses, she holds the view that there are millions of viruses yet to be discovered, and these have the potential to evolve into pandemics.

4. “In a sense, we got lucky with Covid-19, despite the fact that it caused 20 million or more deaths across the world. The point is that the vast majority of people infected with the virus managed to recover. Imagine Disease X is as infectious as measles with the fatality rate of Ebola [67%]. Somewhere in the world, it’s replicating, and sooner or later, somebody will start feeling sick.”

5. The rise in outbreaks, according to Bingham, is attributed to the growing trend of more people congregating in urban areas. She also emphasizes that the continual destruction of millions of acres of natural habitat each year is contributing to this increase.

6. “This reason is particularly important, because around three-quarters of emerging infectious diseases originate in animals and then leap from species to species until they can, in certain circumstances, infect human beings.”

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7. According to Bingham, one of the initial actions that need to be taken is to allocate the necessary financial resources, essentially putting “the money on the table.” Bingham said, ” The monetary cost of inaction is seismic. After all, even Covid-19 – a milder virus than Disease X – managed to leave us holding a bill for $16 trillion in both lost output and public health expenditure.”

8. Regarding vaccines for Disease X, there are currently no approved vaccines available. Nevertheless, Bingham underscores the importance of scientists developing a collection of “different prototype vaccines for every threatening virus family”. She stressed that only a ‘head start’ on vaccines could help to target specific features of Disease X.

9. Bingham explained about the portfolio strategy – vaccines countering different facets of the virus. She explains by saying that ‘different types of vaccines stimulate different immune responses and therefore they provide different levels of protection’.

10. She further noted that the manufacturing capabilities vary enormously across countries and regions. Some vaccine formats may be suitable for large-scale production, while others may be easier to produce in the third world. Third, we need to address the shortcomings of current vaccines, not all of which are durable, easy to transport or cheap. Fourth, researchers must be encouraged to trial new technologies and approaches to vaccine design, potentially leading to more effective and efficient vaccines in the future.”

Read more at-https://shorturl.at/einQ3

 

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COVID-19 Government Guidelines Medical Equipments Medical Updates

Immune cells are critical to efficacy of coronavirus vaccinations: Study

Immune cells are critical to efficacy of coronavirus vaccinations: Study

The study shows that vital subset of immune system cells that are required for successful vaccination of covid.

A study has provided fresh information on a vital subset of immune system cells required for successful vaccination against the SARS-CoV-2 pandemic virus.

The study, led by researchers at NYU Grossman School of Medicine and the New York Genome Centre, focused on T cells, which, along with B cells, form the human immune system’s response to invading viruses and bacteria. T lymphocytes labelled with the surface protein CD8 generate chemicals that kill infected cells directly. B cells secrete antibodies, which neutralise and mark contaminated cells for removal from the body.’

Vaccines expose patients to a bit of an invading bacterium in order to generate responses such as B and T cell activation so that the system is ready for the invader if it is met again. The COVID-19 mRNA vaccines were based on RNA, a genetic material utilised to encode the spike protein required by the virus to adhere to human cells. When mRNA instructions are injected, the spike is generated, and the immune response is activated.

In the rush to create vaccines against SARS-CoV-2, clinical trials relied mostly on antibody levels, when efficient diagnostics were available, to determine whether patients’ immune responses to mRNA vaccine candidates were protective. However, clinical protection was observed as early as ten days following the initial vaccine dose, well before neutralising antibodies could be produced. T cells were thought to be at least as significant in this protection, but normal methods for tracking them were too sluggish, so careful examinations of CD8 T cell responses were put on hold.

Immune cells are critical to efficacy of coronavirus vaccinations: Study

The study published in Nature Immunology describes a quick (high-throughput) approach for tracking T cell responses, demonstrates that they are critical to the early protection afforded by mRNA vaccines against COVID-19, and identifies the T cell subsets most responsible for it.

Our study identified markers for the CD8 T cells that arise from mRNA vaccination and that track closely with successful vaccination, which had previously been difficult to quantify on the population level,” said co-first study author Rabi Upadhyay, MD, assistant professor in the Department of Medicine at NYU Langone Health, and faculty in its Perlmutter Cancer Center.

“Although our study looks at mRNA vaccination against coronavirus, the antigen-specific CD8 T cell subpopulations we uncover represent key features of immune responses more broadly, and may help us to study T cells in other disease settings.”

For the current study, the research team analyzed gene expression over time in single T cells collected before and after immunization with the mRNA vaccine produced by BioNTech and Pfizer against SARS-CoV-2.

The researchers found distinct subsets of CD8 T cells that reliably multiplied (proliferated) 21 days after the original vaccination, specifically targeting and attacking key proteins (antigens) that make up the pandemic virus.

In looking at the genetic makeup of the most effective T cells, the researchers observed that cells lacking a surface protein called KLRG1, which stands for co-inhibitory receptor killer-cell lectin-like receptor G1, were the most likely to multiply quickly after mRNA vaccination and specifically attack.

When study authors checked for these profiles in hospitalized COVID-19 patients, those with the most “properly programmed” T cells – lacking KLRG1 but expressing other markers such as CD38 and HLA-DR – were the most likely to successfully recover from their infections.

In the years since the pandemic began, mRNA vaccines, first used against the virus, are now in clinical trials wherein they direct the body’s immune system to attack cancerous cells.

By clarifying T cell markers (e.g. KLRG1, CD38, HLA-DR), and the timeline for when CD8 T cells arise in the blood after vaccination, the new work may enable clinical teams to tell which patients are responding to the vaccines within days or weeks, say the authors.

That compares to the more than two months that oncologists must currently wait after mRNA vaccination to perform CT scans and assess whether their lung, breast, or prostate cancer patients responded to an mRNA vaccine.

If they are validated in this setting and dramatically shorten such wait times, the new profiling methods promise to help patients pivot more quickly to other treatments if necessary, the researchers say.

Furthermore, the study authors refer to a recent study led by a different research team which found that T cells with very similar attributes, again involving KLRG1, CD38, and HLA-DR, were the most effective at attacking cancer cells after treatment with an immune system-triggering drug (immunotherapy), just as they were the most effective at attacking the SARS-CoV-2 virus in the current study.

“It is remarkable that T cell attributes found after treatment with an effective immunotherapy mirrored those that we found to track with patient recovery from COVID-19,” said co-corresponding author Dan Littman, MD, PhD, the Helen L. and Martin S. Kimmel Professor of Molecular Immunology in the Department of Cell Biology at NYU Langone. “This pattern suggests that the close monitoring of antigen-specific CD8 T cell subpopulations will be central to future efforts to design treatments and vaccines against either viruses or tumours.”

Read more at-https://shorturl.at/HKRY1

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COVID-19 Medical Equipments Medical Updates Medicine & Health

Older adults with COPD had depression during COVID pandemic: Study

Older adults with COPD had depression during COVID pandemic: Study

According to a new longitudinal study published online in the International Journal of Chronic Obstructive Pulmonary Disease (COPD), older persons with COPD were at a higher risk of depression during the early phases of the COVID-19 epidemic

The study looked at 875 people with COPD from the Canadian Longitudinal Study on Ageing, a national study of Canadian seniors. Using longitudinal data, researchers were able to distinguish between 369 COPD patients who had a history of depression previous to the pandemic and 506 patients who had never experienced depression prior to the pandemic.

Researchers discovered that 1 in 6 people with COPD who had no prior history of depression experienced depression for the first time during the early phases of the pandemic. These findings show the toll that the epidemic inflicted on many people who had previously been depression-free.

“Our findings highlight the substantial burden of COVID-19 on those who were mentally healthy prior to the pandemic,” said first author Aneisha Taunque, research assistant at the Institute for Life Course and Aging at the University of Toronto. “It is evident that the pandemic has had a detrimental impact on the mental health of many individuals, even those who had no lifetime history of depression.”

When the analysis was restricted to those who had a history of depression prior to the pandemic, the prevalence of depression was substantially higher, with approximately one-half of these individuals experiencing a recurrence or persistence of depression during the autumn of 2020.

Older adults with COPD had depression during COVID pandemic: Study

“Older adults who have a history of depressive episodes are a highly vulnerable subset of the population, particularly those who faced numerous challenges with managing their chronic health conditions during the pandemic when access to regular health care was severely disrupted,” said co-author Grace Li, PhD candidate in the Sociology Department at the University of Victoria.

“The COVID-19 pandemic further exacerbated the risk of depression among those with COPD,” says co-author Ishnaa Gulati, a Master of Public Health Student at the University of Toronto’s Dalla Lana School of Public Health. “There was already an established higher risk of depression among individuals with COPD when compared to those without COPD prior to the pandemic,” Gulati said. “When considering the mental health stressors during the pandemic, such as extended periods of lockdown, economic precarity, and concerns about contracting or spreading COVID-19, it is unsurprising that this group experienced major mental health challenges during this period.”

Although there is a burgeoning body of research examining depression during the pandemic, very little research has specifically examined the vulnerabilities among those with COPD. Understanding the risk factors for depression in subpopulations of older adults can aid health professionals in more effectively targeting treatment.

The study’s researchers highlighted several risk factors for both incident and recurrent depression among those with COPD, including loneliness, family conflict, and functional limitations.

“We found that experiencing functional limitations approximately doubled the risk of depression among older adults with COPD,” said co-author Ying Jiang, Senior Epidemiologist at the Public Health Agency of Canada.

“Physical activity is integral for maintaining functional status and reducing functional limitations among COPD patients, however many individuals with COPD are hesitant to engage in physical activity. Increases in time spent sedentary during periods of lockdown may have further ramifications for this population, potentially contributing to increases in depression.”

Women with COPD also had nearly double the risk of recurrent depression when compared to their male counterparts.

“During the pandemic, many women experienced an exacerbation of gendered roles, such as increased time spent caregiving and doing household labour, which may have contributed to declines in their mental health,” said co-author Margaret de Groh, Scientific Manager at the Public Health Agency of Canada.

Among individuals with no history of depression, experiencing disruptions to healthcare access was associated with approximately double the risk of incident depression.

“Many people with COPD encountered difficulties accessing pulmonary rehabilitation services during the pandemic, which are essential for supporting both the physical and mental health of COPD patients,” said co-author Andie MacNeil, research assistant at the University of Toronto’s Factor Inwentash Faculty of Social Work (FIFSW).

“Our finding that disruptions to healthcare access were associated with incident depression highlights the reverberating consequences when healthcare is inaccessible.”

Senior author, Esme Fuller-Thomson, a Professor at FIFSW and Director of the Institute for Life Course & Aging says she hopes the study’s findings can help inform healthcare workers and social service providers about the pandemic’s impact on the mental health of people with COPD. “Future research should continue to examine depression among older adults with COPD to better understand the pandemic’s cascading impact, even in the post-COVID era,” Fuller-Thomson said.

Read more at-https://shorturl.at/lmEJV

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Medical Updates Medicine & Health

World Alzheimer’s Day: 7 things you should do every day to cut Alzheimer’s disease risk

World Alzheimer's Day: 7 things you should do every day to cut Alzheimer's disease risk

World Alzheimer’s Day: While there is no cure of Alzheimer’s the disease can be avoided by following certain lifestyle habits.

Alzheimer’s disease can have a devastating impact on one’s life. The neurological disease shrinks the brain and over a course of time diminishes thinking, memory, and social skills. In advanced stage, people with Alzheimer’s are completely dependent on their caretakers and eventually with severe loss of brain function, people can suffer from dehydration, malnutrition or infection. This can even turn fatal and cause death. Studies prove that chances of Alzheimer’s can be reduced with lifestyle modifications be it regular physical activity, good diet, managing stress and chronic conditions. (Also read: World Alzheimer’s Day 2023: Date, history, significance)

As per researchers, compared to people with no or one healthy lifestyle factors, the risk of Alzheimer’s was 37% lower in those with two to three, and 60% lower in those with four to five healthy lifestyle factors. The lifestyle factors in this study include at least 150 minutes per week of moderate to vigorous-intensity physical activity, not smoking, light-to-moderate alcohol consumption, a high-quality, mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and engagement in late-life cognitive activities.

“Alzheimer’s disease poses a devastating global challenge, impacting millions of individuals. While a definitive cure remains elusive, mounting evidence suggests that adopting specific lifestyle choices can mitigate the likelihood of developing this debilitating ailment. By integrating the following seven habits into your daily regimen, you can proactively safeguard your brain health and diminish the risk of Alzheimer’s,” says Dr Neha Kapoor, Associate Director & Head-Neurology, Asian Hospital Faridabad.

On the occasion of World Alzheimer’s Day (September 21), here are factors that can help reduce risk of the disease.

World Alzheimer's Day: 7 things you should do every day to cut Alzheimer's disease risk

Lifestyle habits that can help cut Alzheimer’s risk

1. Embrace a heart-healthy diet

Cultivate a diet abundant in fruits, vegetables, whole grains, and lean proteins to bolster brain health. Prioritize foods rich in antioxidants, such as berries and leafy greens, which combat brain inflammation and oxidative stress. Additionally, incorporate omega-3 fatty acids from sources like salmon and walnuts to further reduce Alzheimer’s risk.

2. Engage in regular physical activity

Establish a consistent exercise routine to enhance overall health and decrease Alzheimer’s susceptibility. Strive for a minimum of 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity activity weekly. Exercise stimulates improved cerebral blood circulation, fosters the release of brain-protective compounds, and maintains optimal brain tissue health.

3. Foster mental stimulation

Keep your cognitive faculties engaged through regular challenges. Activities like reading, puzzles, acquiring new skills, and participating in intellectually stimulating conversations fortify cognitive reserves, potentially delaying the onset of Alzheimer’s symptoms.

4. Prioritize quality sleep

Give your brain the restorative sleep it needs by aiming for 7-9 hours of nightly rest. Inadequate sleep patterns and sleep-related disorders are associated with heightened cognitive decline and Alzheimer’s risk.

5. Manage stress

Chronic stress can detrimentally impact brain health. Incorporate stress-reduction techniques into your daily routine, such as mindfulness meditation, yoga, deep breathing exercises, or enjoyable hobbies. Reducing stress levels can safeguard your brain against harm caused by excessive cortisol production.

6. Cultivate social connections

Social engagement is a cornerstone of brain health. Regular interaction with friends and family, participating in group activities, and nurturing social ties can preserve cognitive function. Loneliness and isolation are linked to an increased Alzheimer’s risk.

7. Monitor chronic health conditions

Maintain vigilance over your overall health, particularly conditions like hypertension, diabetes, and high cholesterol, as they elevate Alzheimer’s risk. Collaborate closely with your healthcare provider to effectively manage these conditions.

“Adopting these habits into your daily life can significantly diminish your Alzheimer’s risk. Consistent, long-term practice is crucial for their effectiveness. Additionally, consult a healthcare professional for personalized guidance in crafting a brain-healthy lifestyle tailored to your specific needs and risk factors. Proactive care for your brain enhances the prospect of enjoying a vibrant and cognitively sound life as you age,” says Dr Kapoor.

Read more at-https://shorturl.at/aPW79

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Government Guidelines Medical Updates Medicine & Health

Nipah virus outbreak: Top 10 symptoms of the deadly virus; prevention and treatment tips

Nipah virus outbreak: Top 10 symptoms of the deadly virus; prevention and treatment tips

While Nipah virus starts with mild symptoms like headache, muscle pain, fatigue, nausea, it may progress to deadly symptoms as the disease advances.

Amid the outbreak of Nipah virus in Kerala, the state has been taking all the precautionary measures to control the spread. So far, two people have died and at least five have been infected by the virus which has high mortality rate but is less infectious.

WHO says the Nipah virus’s fatality rate may be between 40- 75 percent. Nipah virus is a viral infection and the name ‘Nipah’ comes from a Malaysian village, where the first outbreak was reported in 1998-1999 and it has high mortality.

While Nipah virus starts with mild symptoms like headache, muscle pain, fatigue, nausea, it may progress to mental confusion, seizures and encephalitis when the virus starts affecting brain function.

What is Nipah virus?

“Nipah virus (NiV) is a zoonotic virus that can cause severe illness in humans. It is primarily transmitted from animals to humans and can also spread from human to human. The symptoms of Nipah virus infection can range from mild to severe,” says Dr Ajay Aggarwal, Director – Internal Medicine, Fortis Hospital Noida.

“Nipah virus was first identified in 1998 during an outbreak in Malaysia. Nipah virus infection can lead to severe respiratory illness and encephalitis (inflammation of the brain),” says Dr G Sneha, Consultant – General Medicine, CARE Hospitals, Banjara Hills, Hyderabad.

“Nipah virus is primarily seen in Indo Bangladesh region. In Malaysia, the source of infection was nosocomial, the source being pigs and bats who had transmitted the virus to humans. Consecutively, human to human infection is the cause of spread of the infection through droplet infection. Recently, two unnatural deaths were reported in Kozhikode, Kerela suspected to be due to a new virus outbreak in the area. It is feared that the deaths might be caused due to the Nipah virus,” says Dr Tushar Tayal, Consultant, Internal Medicine, CK Birla Hospital, Gurugram.

Symptoms of Nipah virus

Initial symptoms of Nipah virus are non-specific such as fever, headache, dizziness, myalgia, vomiting and loose stools. This may progress to brain involvement in the form of seizures and encephalitis. There may also be respiratory involvement causing respiratory failure.

“Nipah infection has very high morbidity in the form of psychiatric and neurological complications (depression, personality changes, deficits in attention, verbal, and/or visual memory) after recovery. Mortality rate of Nipah is also very high as it is majorly untraceable, and has a fatality rate of 40 to 75 percent, according to the World Health Organisation (WHO),” says Dr Tayal.

Dr Ajay Agarwal shares Nipah virus’s symptoms in detail:

1. Fever: Nipah virus infection often starts with a high fever.

2. Headache: Headaches are a common early symptom.

3. Muscle pain: Muscle aches and pain may occur, similar to flu-like symptoms.

4. Fatigue: Profound weakness and fatigue can be present.

5. Nausea: Many individuals experience nausea, sometimes accompanied by vomiting.

6. Dizziness: Some people may feel dizzy or lightheaded.

7. Mental confusion: As the disease progresses, confusion and disorientation may develop.

8. Seizures: In severe cases, individuals may experience seizures due to neurological complications.

9. Respiratory symptoms: Respiratory distress, including difficulty breathing, can occur in severe cases.

10. Coma: In the most severe cases, individuals can slip into a coma.

Dr G Sneha shares the following symptoms for Nipah virus

Fever: Nipah virus infection often begins with a high fever, typically 3 to 14 days after exposure.

Headache: Severe headaches are common.

Dizziness: Patients may experience dizziness or disorientation.

Nausea and vomiting: Gastrointestinal symptoms like nausea and vomiting may occur.

Neck rigidity: Stiff neck and muscle pain can be early signs of the infection.

Mental confusion: As the disease progresses, patients may become disoriented and develop mental confusion.

Coma: In severe cases, Nipah virus infection can lead to a coma within 24-48 hours.

“Furthermore, it’s crucial to take precautions to prevent Nipah virus transmission, as it can spread from person to person through close contact, respiratory droplets, or contact with contaminated objects or surfaces. Public health measures such as isolation, quarantine, and infection control practices are essential to prevent outbreaks of Nipah virus infection. If you suspect a Nipah virus outbreak in your area or have concerns about potential exposure, it’s essential to contact local health authorities for guidance and follow recommended preventive measures,” says Dr Agarwal.

Nipah virus outbreak: Top 10 symptoms of the deadly virus; prevention and treatment tips

Treatment

Dr G Sneha says there is no specific antiviral treatment for Nipah virus infection and supportive care is the mainstay of treatment.

It may include:

1. Hospitalization: Infected individuals are usually hospitalized to receive appropriate medical care and to prevent the spread of the virus.

2. Supportive care: This includes intravenous fluids to maintain hydration, pain management, and mechanical ventilation in severe cases to assist with breathing.

3. Experimental treatments: In some cases, experimental antiviral drugs or therapies may be considered, but their effectiveness is not well established.

“Also, there are very few experimental medications such as Ribavirin and favipiravir which have shown some benefit, but the treatment remains primarily symptomatic,” says Dr Tayal.

Management

Dr G Sneha suggests Nipah virus patient should be isolated and quarantined. Here are points to remember:

1. Isolation and quarantine: Infected hould be isolated to prevent further transmission. Close contacts should be monitored and quarantined if necessary.

2. Infection control: Healthcare workers and caregivers should follow strict infection control measures to prevent the spread of the virus.

3. Preventive measures: In areas with known Nipah virus outbreaks, measures such as avoiding contact with sick animals, not consuming fruits contaminated by bat saliva or urine, and practicing good hygiene are important for prevention.

4. Vaccines: Research is ongoing, and vaccines are being developed, but as of my last update in September 2021, there was no licensed vaccine for Nipah virus.

“Hand hygiene and personal protective equipment (PPE) remain as pillars of comprehensive infection prevention. We have to remember our learning from Covid and use the same precautions that we have been following for the past few years that is hand hygiene, social distancing and usage of masks,” says Dr Tayal.

Read more at-https://shorturl.at/osuB2

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COVID-19 Medical Updates Medicine & Health

Heart attack cases not rising due to Covid vaccine, but stress and other traditional factors, says cardiologist

10 things you can do for your mental health every day

Dr Mohit Gupta from GB Pant Hospital who was part of a new study published in the journal PLOS One, says Covid vaccine is in fact providing protection to heart.

The administration of Covid vaccines to a wide population across the globe has helped bring Coronavirus threat in control. While the virus continues to evolve and new variants are emerging, the symptoms are milder than early pandemic years. Irrespective of the role Covid vaccines played in controlling the spread of the virus, the reports of its side effects, especially its role in triggering heart attack is often debated by common people. A new observational study published in the journal PLOS One, determines the impact of Covid-19 vaccination on mortality following heart attack or acute myocardial infarction (AMI).

The study concludes that Covid vaccines Covishield and Covaxin do not pose as a risk factor for a heart attack and in fact have a protective effect on heart.

“The retrospective study used data from 1,578 people admitted to G B Pant hospital in Delhi between August 2021 and August 2022. As many as 1,086 (68.8 per cent) were vaccinated against COVID-19 while 492 (31.2 per cent) were unvaccinated,” reported PTI.

Among the vaccinated group, 1,047 (96 per cent) had received two doses of the vaccine while 39 (4 per cent) had received only a single dose.

Heart attack cases not rising due to Covid vaccine, but stress and other traditional factors, says cardiologist

“We analysed patients detected with heart attack in our set up. Many of them were vaccinated and some of them were not so retrospectively, we started analysing them and what we saw was very surprising. When these patients were taken for vaccination, the vaccine administration was absolutely safe, they didn’t have any significant side effects that could be linked to heart attack. It was concluded that there was no association between vaccine administration and occurrence of heart attack,” says Dr Mohit Gupta, Interventional Cardiologist and Professor of cardiology, who led the study, from G B Pant Hospital.

Dr Mohit added that they found that people who were vaccinated had lesser risk of heart attack compared to unvaccinated lot which means the vaccine in fact had a protective effect for cardiovascular health.

“This study conclusively point out that what we are using is safe and if one gets vaccinated it will give protection. Covid vaccination will be like influenza vaccine which would be given every year. With new variants, vaccines will be updated,” says Dr Mohit.

While the study rules out Covid vaccine’s role in triggering heart attack, the cases are on rise after pandemic.

“India is evolving into a world capital of heart attack because of many factors and traditional factors like diabetes, obesity, hypertension, smoking are always there. Patterns and prevalence of these diseases are changing due to genetics also. Indians are more prone to heart attack than earlier. Second, factors like psychosocial stress, like anger, they are now having third highest predictive value of heart attacks. Our own analysis of 1700 patients showed 95% of population is suffering from severe to moderate stress in some way or the other. We are still bind-folded and not accepting this risk factor. 25% of heart attack population is between 18 to 35 years of age. They study telomere length or genetic length. You would be surprised that without any risk factor, their body age was 25 to 30 years, but their genetic age was 60 to 90 years. This is happening because their telomere length was completely destroyed,” says Dr Mohit Gupta.

Read more at-https://shorturl.at/mGMS3

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COVID-19 Government Guidelines Medical Updates

Updated COVID vaccine effective against newer variant, says Moderna

Updated COVID vaccine effective against newer variant, says Moderna

Moderna has said clinical trial data showed its updated COVID-19 vaccine will likely be effective against the highly-mutated BA.2.86 subvariant of the coronavirus that has raised fears of a resurgence of infections.

Moderna has said that the clinical trial data showed its updated COVID-19 vaccine shot generated an 8.7-fold increase in neutralizing antibodies in humans against the highly-mutated BA.2.86 subvariant of the coronavirus that has raised fears of a resurgence of infections, Reuters reported on Wednesday.

“We think this is news people will want to hear as they prepare to go out and get their fall boosters,” Reuters quoted Jacqueline Miller head of infectious diseases in Moderna said in an interview, adding that the data should also help reassure regulators.

The Centers for Disease Control and Prevention (CDC) has previously indicated that BA.2.86 may be more capable of causing infection in people who previously had COVID or were vaccinated with previous shots.

Updated COVID vaccine effective against newer variant, says Moderna

The Omicron offshoot carries more than 35 mutations in key portions of the virus compared with XBB.1.5, the dominant variant through most of 2023 and the target of the updated shots.

Moderna said it had shared the new finding on its vaccine with regulators and submitted it for peer review publication.

The retooled Moderna shot is expected to be available later this month or in early October, though it is yet to be approved by the US Food and Drug Administration.

Meanwhile, rival COVID-19 vaccine manufacturers Novavax and Pfizer with German partner BioNTech have created versions of their shots aimed at the XBB.1.5 subvariant.

In August, Moderna and Pfizer each said their new vaccines appeared to be effective against another new subvariant of concern dubbed EG.5 in initial testing

Britain’s Medicines and Healthcare products Regulatory Agency has approved Pfizer/BioNTech shot, but have not make any announcements on Moderna’s updated vaccine.

A WHO official said the BA.2.86 the subvariant of the coronavirus has been detected in Switzerland, South Africa as well as Israel, Denmark, the US and Britain.

According to experts it is important to monitor the variant, but it is unlikely to cause a wave of severe disease and death because of immune defenses built up worldwide from mass vaccination and prior infection.

Read more at-https://shorturl.at/quyUZ

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COVID-19 Medical Updates Medicine & Health

Covid vaccines used in India and risk of heart attack are not related: Study

Covid vaccines used in India and risk of heart attack are not related:

The study emphasising on the effect of jabs has stated that the risk of heart attacks is not associated with covid vaccines.

There is no association between the Covid-19 vaccines used in India — Covishield and Covaxin — and increase in the risk of heart attacks, according to an observational study which emphasises the protective effect of the jabs.

The research, published recently in the journal PLOS One, determined the impact of COVID-19 vaccination on mortality following acute myocardial infarction (AMI) or heart attack.

The retrospective study used data from 1,578 people admitted to G B Pant hospital in Delhi between August 2021 and August 2022. As many as 1,086 (68.8 per cent) were vaccinated against COVID-19 while 492 (31.2 per cent) were unvaccinated.

Among the vaccinated group, 1,047 (96 per cent) had received two doses of the vaccine while 39 (4 per cent) had received only a single dose.

“Our study found that vaccines used in India are safe. There was no association of vaccination in India with heart attack. In fact, the study found that there were less chances of death after heart attack in vaccinated individuals,” Mohit Gupta, who led the study, from G B Pant Hospital, told PTI.

Covid vaccines used in India and risk of heart attack are not related:

The adverse effects (AEs) of COVID-19 vaccines have mostly been mild, transient and self-limiting. However, concerns have been raised regarding the cardiovascular adverse effects of these vaccines.

Any side effect can have catastrophic effects especially in large densely populated countries such as India, the authors noted.

In all the enrolled patients, data regarding the patient’s vaccination status including details on type of vaccine, date of vaccination and adverse effects were obtained.

The researchers found that the analysis did not show a specific clustering of AMI at any particular time post vaccination, suggesting there was no significant association between COVID-19 jabs and heart attacks.

On 30-day follow-up, all-cause mortality occurred in 201 (12.7 per cent) patients with adjusted odds of mortality being significantly lower in the vaccinated group.

Similarly, at six months of follow-up, the vaccinated AMI group had lower odds of mortality as compared to the non-vaccinated group.

COVID-19 vaccines showed a decrease in all-cause mortality at 30 days and six months following AMI, according to the study.

However, increasing age, diabetics and smokers had a higher risk of 30-day mortality, the researchers said.

“Findings of our study showed that the 30-day and six months all-cause mortality risk was significantly lower in the vaccinated subjects as compared to the unvaccinated population,” the authors of the study said.

This study is the first to be conducted among a larger population of AMI patients which has shown COVID-19 vaccine to be not only safe but also have a protective effect in terms of reduction of all-cause mortality both on short term as well as at six months of follow-up, the authors of the study said.

They noted some limitations, saying that this was a single centre retrospective study, and the findings need to be validated in further larger studies from different ethnic groups.

Read more at-https://shorturl.at/oxY25